Acute Myeloid Leukemia Animation
Scientific Animation | Investor Relations & Website Assets
Acute myeloid leukemia (AML) is a type of blood cancer of monocyte or granulocyte cells. Using vibrant, eye-catching 3D visuals, this mechanism of action (MoA) animation explores the pathway of an investigational, first-in-class, E-selectin antagonist under development for relapsed/refractory AML.
The MoA animation provides a concise overview of AML, describing it as a clonal malignant disorder that originates in the bone marrow. In this environment, leukemic stem cells are believed to undergo genetic and molecular changes, which can lead to the production of blast cells that may disrupt normal hematopoiesis.
As a result, these blast cells can accumulate, potentially creating an environment that supports their survival through cytokine secretion and activation of receptors on vascular endothelial cells. This process is thought to lead to increased expression of the adhesion protein E-selectin, which may enable leukemic cells to evade cytotoxic therapies effectively.
Having presented the context for the disease’s progression, the animation introduces an investigational glycomimetic compound designed to disrupt the chemoprotective mechanism potentially provided by E-selectin and NF-κB. By doing so, the compound aims to render the leukemic cells more susceptible to various therapies, with the goal of supporting treatment outcomes and potentially contributing to the restoration of healthy bone marrow.
The primary aim of this educational animation was to visually represent the story of E-selectin antagonism in AML, presenting complex scientific concepts in an engaging and easily understandable manner.
Tailored for investors, this video effectively conveys the science behind the investigational treatment in a captivating, digestible format.
Additionally, the animation has been adapted for social media and web-based applications, with content featured across the GlycoMimetics website as banner imagery and the video embedded on their homepage and product page. Moreover, the animation is prominently displayed on the GlycoMimetics YouTube channel, aiming to ensure widespread accessibility to this information.
View full animation below.
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