Immunoproteasome Animation | KZR-616 Selective Inhibitor


We created a scientific animation for Kezar Life Sciences focusing on the normal function of the multicatalytic immunoproteasome, emphasizing its importance in the body. The animation then illustrates the disease state, whereby the immunoproteasome becomes highly expressed at the sites of inflammation in patients with autoimmune disorders. The mechanism of action (MoA) of selective inhibitor of the immunoproteasome, KZR-616, is explained and how it induces a potent anti-inflammatory effect, resulting in symptom improvement and disease remission in Rheumatoid Arthritis, lupus, Multiple Sclerosis, and Inflammatory bowel disease.

The purpose of the animation was to provide a visual explanation of the normal function, disease state and MoA of KZR-616 in a comprehensive and engaging manner so that the science and subsequent beneficial outcomes can be clearly understood by the appropriate target audiences.

The animation was created for use at industry trade shows and conferences, for corporate fundraising events and investor relations.

The video can currently be found on the immunoproteasome section of the Kezar Life Sciences website and visual assets utilized throughout their 2019 Investor Presentation.

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‘‘Extremely happy, everybody was great on the team. They answered all our questions and made it look easy. The end result is perfect.
Executive Coordinator, Cellectar Biosciences


‘‘The presentation was dramatically enhanced by the video, which looked fantastic on the big screen. Thank you and the entire Random42 team for your excellent work and for getting the final edition to me in time for the conference. All very much appreciated!
President and CEO, Vallum Corporation

‘‘It was a combination equally of quality of work but also the comfort and confidence that I knew I would be working with PhDs. They gave me the confidence that they would have the ability to understand. The other companies didn’t have those sorts of people on staff, they were just good animators. That was the area where I felt that I could trust Random42 would deliver.’’
Senior Product Manager, Spectranetics

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‘‘I have been to a lot of conferences and I have seen a lot of videos both from competitors and internally – in my eyes it is night and day. The quality Random42 have is not one step ahead, it is far ahead compared to what I have seen before.’’
Product Manager, Amgen